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1

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

John Lloyd, Heather J. Finlay, Wayne Vacarro, Tram Hyunh, Alexander Kover, Rao Bhandaru, Lin Yan, Karnail Atwal, Mary Lee Conder, Tonya Jenkins-West, Hong Shi, Christine Huang, Danshi Li, Huabin Sun,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 640 KB

english, 2010

2

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

Karnail S. Atwal, Steven V. O’Neil, Saleem Ahmad, Lidia Doweyko, Mark Kirby, Charles R. Dorso, Gamini Chandrasena, Bang-Chi Chen, Rulin Zhao, Robert Zahler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 120 KB

english, 2006

3

Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors

Yan Shi, Jing Zhang, Philip D. Stein, Mengxiao Shi, Stephen P. O’Connor, Sharon N. Bisaha, Chi Li, Karnail S. Atwal, Gregory S. Bisacchi, Doree Sitkoff, Andrew T. Pudzianowski, Eddie C. Liu, Karen S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 168 KB

english, 2005

4

Synthesis and biological activity of novel calcium channel blockers: 2,5-dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters and 2,5-dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic acid esters

Atwal, Karnail S., Bergey, James L., Hedberg, Anders, Moreland, Suzanne

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 880 KB

english, 1987

5

Substituted 1,2,3,4-tetrahydroaminonaphthols: antihypertensive agents, calcium channel blockers, and adrenergic receptor blockers with catecholamine-depleting effects

Atwal, Karnail S., O'Reilly, Brian C., Ruby, Eric P., Turk, Chester F., Aberg, Gunnar, Asaad, Magdi M., Bergey, James L., Moreland, Suzanne, Powell, James R.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 1.23 MB

english, 1987

6

ChemInform Abstract: A New Facile Method for the Stereoselective Synthesis of trans-2-Aryl-3,3-dimethylcyclopropane-1-carboxylic Acids.

Bang-Chi Chen, Khehyong Ngu, Peng Guo, Wen Liu, Joseph E. Sundeen, David S. Weinstein, Karnail S. Atwal, Saleem Ahmad

Journal:

Year:

2001

File:

PDF, 32 KB

2001

7

ChemInform Abstract: One-Pot Synthesis of N,N′-Disubstituted Acylguanidines.

Jing Zhang, Yan Shi, Philip Stein, Karnail Atwal, Chi Li

Journal:

Year:

2002

File:

PDF, 28 KB

2002

8

One-Pot Synthesis and Conformational Features of N,N′-Disubstituted Ketene Aminals.

Yan Shi, Jing Zhang, Nyeemah Grazier, Philip D. Stein, Karnail S. Atwal, Sarah C. Traeger, Sharon P. Callahan, Mary F. Malley, Michael A. Galella, Jack Z. Gougoutas

Journal:

Year:

2004

File:

PDF, 138 KB

2004

9

N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine Derivatives as Potent Inhibitors of the Bovine Mitochondrial F1F0 ATP Hydrolase.

Karnail S. Atwal, et al. et al.

Journal:

Year:

2004

File:

PDF, 94 KB

2004

10

Benzodiazepine-Based Selective Inhibitors of Mitochondrial F1F0 ATP Hydrolase.

Lawrence G. Hamann, Charles Z. Ding, Arthur V. Miller, Cort S. Madsen, Paulina Wang, Philip D. Stein, Andrew T. Pudzianowski, David W. Green, Hossain Monshizadegan, Karnail S. Atwal

Journal:

Year:

2004

File:

PDF, 123 KB

2004

11

Advances in the structure-activity relationships, mechanisms of action, and therapeutic utilities of ATP-sensitive potassium channel openers

Dr. Karnail S. Atwal

Journal:

Drug Development Research

Year:

1994

Language:

english

File:

PDF, 1.24 MB

english, 1994

12

Modulation of potassium channels by organic molecules

Karnail S. Atwal

Journal:

Medicinal Research Reviews

Year:

1992

Language:

english

File:

PDF, 1.38 MB

english, 1992

13

Trimethylaluminum promoted synthesis of cyanoguanidines

Karnail S. Atwal, Francis N. Ferrara, Syed Z. Ahmed

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 227 KB

english, 1994

14

Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1

Saleem Ahmad, Khehyong Ngu, Donald W Combs, Shung C Wu, David S Weinstein, Wen Liu, Bang-Chi Chen, Gamini Chandrasena, Charles R Dorso, Mark Kirby, Karnail S Atwal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 177 KB

english, 2004

15

Benzodiazepine-based selective inhibitors of mitochondrial F1F0 ATP hydrolase

Lawrence G. Hamann, Charles Z. Ding, Arthur V. Miller, Cort S. Madsen, Paulina Wang, Philip D. Stein, Andrew T. Pudzianowski, David W. Green, Hossain Monshizadegan, Karnail S. Atwal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 160 KB

english, 2004

16

N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F1F0 ATP hydrolase

Karnail S. Atwal, Saleem Ahmad, Charles Z. Ding, Philip D. Stein, John Lloyd, Lawrence G. Hamann, David W. Green, Francis N. Ferrara, Paulina Wang, W.Lynn Rogers, Lidia M. Doweyko, Arthur V. Miller, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 175 KB

english, 2004

17

Benzopyran sulfonamides as KV1.5 potassium channel blockers

John Lloyd, Karnail S. Atwal, Heather J. Finlay, Michael Nyman, Tram Huynh, Rao Bhandaru, Alexander Kover, Joan Schmidt, Wayne Vaccaro, Mary Lee Conder, Tonya Jenkins-West, Paul Levesque

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 141 KB

english, 2007

18

Pyrano-[2,3b]-pyridines as potassium channel antagonists

Heather J. Finlay, John Lloyd, Michael Nyman, Mary Lee Conder, Tonya West, Paul Levesque, Karnail Atwal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 146 KB

english, 2008

19

Synthesis and evaluation of acylguanidine FXa inhibitors

Stephen P. O’Connor, Karnail Atwal, Chi Li, Eddie C.-K. Liu, Steven M. Seiler, Mengxiao Shi, Yan Shi, Philip D. Stein, Ying Wang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 251 KB

english, 2008

20

Dihydropyrazolopyrimidine Inhibitors of KV1.5 (IKur)

Wayne Vaccaro, Tram Huynh, John Lloyd, Karnail Atwal, Heather J. Finlay, Paul Levesque, Mary Lee Conder, Tonya Jenkins-West, Hong Shi, Lucy Sun

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 209 KB

english, 2008

21

Dihydropyrazolopyrimidines containing benzimidazoles as KV1.5 potassium channel antagonists

John Lloyd, Heather J. Finlay, Karnail Atwal, Alexander Kover, Joseph Prol, Lin Yan, Rao Bhandaru, Wayne Vaccaro, Tram Huynh, Christine S. Huang, MaryLee Conder, Tonya Jenkins-West, Huabin Sun, Danshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 556 KB

english, 2009

22

A facile synthesis of cyanoguanidines from thioureas

Karnail S. Atwal, Syed Z. Ahmed, Brian C. O'Reilly

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 220 KB

english, 1989

23

An isomerization—claisen rearrangement route to olefinic dicarbonyl starting materials for conjugate cyclization

Gilbert Stork, Karnail S. Atwal

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 175 KB

english, 1982

24

On the stereochemistry of photoaddition between α,β-unsaturated ketones and olefins. III.

John F. Blount, Glenna D. Gray, Karnail S. Atwal, Thomas Y.R. Tsai, Karel Wiesner

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 169 KB

english, 1980

25

Acid catalyzed intramolecular conjugate addition as a route to trans hydrindane systems

Gilbert Stork, Karnail S. Atwal

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 166 KB

english, 1983

26

A new facile method for the stereoselective synthesis of trans-2-aryl-3,3-dimethylcyclopropane-1-carboxylic acids

Bang-Chi Chen, Khehyong Ngu, Peng Guo, Wen Liu, Joseph E Sundeen, David S Weinstein, Karnail S Atwal, Saleem Ahmad

Journal:

Tetrahedron Letters

Year:

2001

Language:

english

File:

PDF, 53 KB

english, 2001

27

One-pot synthesis of N,N′-disubstituted acylguanidines

Jing Zhang, Yan Shi, Phlip Stein, Karnail Atwal, Chi Li

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 72 KB

english, 2002

28

The discovery of a novel calcium channel blocker related to the structure of potassium channel opener cromakalim

Karnail S. Atwal, John R. McCullough, Anders Hedberg, Mary L. Conder, Syed Z. Ahmed, Gabriella Cucinotta, Diane E. Normandin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 351 KB

english, 1992

29

Benzopyranyl-cyanoguanidine potassium channel openers

Karnail S. Atwal, Suzanne Moreland, John R. McCullough, Syed Z. Ahmed, Diane E. Normandin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 287 KB

english, 1992

30

Aryl cyanoguanidine potassium channel openers

Karnail S. Atwal, Suzanne Moreland, John R. McCullough, Brian C. O'Reilly, Syed Z. Ahmed, Diane E. Normandin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 298 KB

english, 1992

31

(cis)-3-methyl-1,5-benzothiazepine-4-ones: potent analogs of the calcium channel blocker diltiazen

Karnail S. Atwal, Syed Z. Ahmed, David M. Floyd, Suzanne Moreland, Anders Hedberg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 271 KB

english, 1993

32

Erratum to “Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors” [Bioorg. Med. Chem. Lett. 15 (2005) 5453–5458]

Yan Shi, Jing Zhang, Philip D. Stein, Mengxiao Shi, Stephen P. O’Connor, Sharon N. Bisaha, Chi Li, Karnail S. Atwal, Gregory S. Bisacchi, Doree Sitkoff, Andrew T. Pudzianowski, Eddie C. Liu, Karen S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 55 KB

english, 2006

33

Dihydropyrimidine calcium channel blockers 51: bicyclic dihydropyrimidines as potent mimics of dihydropyridines

Karnail S. Atwal, Suzanne Moreland

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1991

Language:

english

File:

PDF, 312 KB

english, 1991

34

BMS-180448, A Glyburide-Reversible Cardioprotective Agent with Minimal Vasodilator Activity

Gary J. Grover, Karnail S. Atwal

Journal:

Cardiovascular Therapeutics

Year:

1995

Language:

english

File:

PDF, 771 KB

english, 1995

35

Pharmacologic Profile of the Selective Mitochondrial-KATP Opener BMS-191095 for Treatment of Acute Myocardial Ischemia

Gary J. Grover, Karnail S. Atwal

Journal:

Cardiovascular Therapeutics

Year:

2002

Language:

english

File:

PDF, 219 KB

english, 2002

36

Substituted 1,4-dihydropyrimidines. 3. Synthesis of selectively functionalized 2-hetero-1,4-dihydropyrimidines

Atwal, Karnail S., Rovnyak, George C., O'Reilly, Brian C., Schwartz, Joseph

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 1.34 MB

english, 1989

37

Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Atwal, Karnail S., Rovnyak, George C., Schwartz, Joseph, Moreland, Suzanne, Hedberg, Anders, Gougoutas, Jack Z., Malley, Mary F., Floyd, David M.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 765 KB

english, 1990

38

Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists

Finlay, Heather J., Jiang, Ji, Caringal, Yolanda, Kover, Alexander, Conder, Mary Lee, Xing, Dezhi, Levesque, Paul, Harper, Timothy, Hsueh, Mei Mann, Atwal, Karnail, Blanar, Michael, Wexler, Ruth, Lloy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 872 KB

english, 2013

39

Dihydropyrimidine calcium channel blockers. II. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Atwal, Karnail S., Rovnyak, George C., Kimball, S. David, Floyd, David M., Moreland, Suzanne, Swanson, Brian N., Gougoutas, Jack Z., Schwartz, Joseph, Smillie, Kaye M., Malley, Mary F.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 821 KB

english, 1990

40

Dihydropyrimidine angiotensin II receptor antagonists

Atwal, Karnail S., Ahmed, Syed Z., Bird, J. Eileen, Delaney, Carol L., Dickinson, Kenneth E. J., Ferrara, Francis N., Hedberg, Anders, Miller, Arthur V., Moreland, Suzanne

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.39 MB

english, 1992

41

Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents

Atwal, Karnail S., Swanson, Brian N., Unger, Steven E., Floyd, David M., Moreland, Suzanne, Hedberg, Anders, O'Reilly, Brian C.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 1.10 MB

english, 1991

42

One-Pot Synthesis and Conformational Features of N,N ‘ -Disubstituted Ketene Aminals

Shi, Yan, Zhang, Jing, Grazier, Nyeemah, Stein, Philip D., Atwal, Karnail S., Traeger, Sarah C., Callahan, Sharon P., Malley, Mary F., Galella, Michael A., Gougoutas, Jack Z.

Journal:

Journal of Organic Chemistry

Year:

2004

Language:

english

File:

PDF, 134 KB

english, 2004

43

Triphenylphosphine Oxide Is a Potent and Selective Inhibitor of the Transient Receptor Potential Melastatin-5 Ion Channel

Palmer, R. Kyle, Atwal, Karnail, Bakaj, Ivona, Carlucci-Derbyshire, Stacy, Buber, M. Tulu, Cerne, Rok, Cortés, Rosa Y., Devantier, Heather R., Jorgensen, Vincent, Pawlyk, Aaron, Lee, S. Paul, Sprous,

Journal:

Assay and Drug Development Technologies

Year:

2010

Language:

english

File:

PDF, 782 KB

english, 2010

44

Dihydropyrimidine calcium channel blockers. 4. Basic 3-substituted-4-aryl-1,4-dihydropyrimidine-5-carboxylic acid esters. Potent antihypertensive agents

Rovnyak, George C., Atwal, Karnail S., Hedberg, Anders, Kimball, S. David, Moreland, Suzanne, Gougoutas, Jack Z., O'Reilly, Brian C., Schwartz, Joseph, Malley, Mary F.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.32 MB

english, 1992

45

Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 4. Structure−Activity Studies on Benzopyranylcyanoguanidines: Replacement of the Benzopyran Portion

Atwal, Karnail S., Ferrara, Francis N., Ding, Charles Z., Grover, Gary J., Sleph, Paul G., Dzwonczyk, Steven, Baird, Anne J., Normandin, Diane E.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 481 KB

english, 1996

46

Design and Synthesis of 4-Substituted Benzamides as Potent, Selective, and Orally Bioavailable I Ks Blockers

Lloyd, John, Schmidt, Joan B., Rovnyak, George, Ahmad, Saleem, Atwal, Karnail S., Bisaha, Sharon N., Doweyko, Lidia M., Stein, Philip D., Traeger, Sarah C., Mathur, Arvind, Conder, Mary Lee, DiMarco,

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 74 KB

english, 2001

47

Cardioselective Anti-Ischemic ATP-Sensitive Potassium Channel Openers. 3. Structure-Activity Studies on Benzopyranyl Cyanoguanidines; Modification of the Cyanoguanidine Portion

Atwal, Karnail S., Grover, Gary J., Ahmed, Syed Z., Sleph, Paul G., Dzwonczyk, Steven, Baird, Anne J., Normandin, Diane E.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.11 MB

english, 1995

48

Cardioselective Antiischemic ATP-Sensitive Potassium Channel (K ATP ) Openers. 5. Identification of 4-( N -Aryl)-Substituted Benzopyran Derivatives with High Selectivity

Rovnyak, George C., Ahmed, Syed Z., Ding, Charles Z., Dzwonczyk, Steven, Ferrara, Francis N., Humphreys, W. Griffith, Grover, Gary J., Santafianos, Dinos, Atwal, Karnail S., Baird, Anne J., McLaughlin

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 646 KB

english, 1997

49

Cardioselective Antiischemic ATP-Sensitive Potassium Channel (K ATP ) Openers. 6. Effect of Modifications at C6 of Benzopyranyl Cyanoguanidines

Ding, Charles Z., Rovnyak, George C., Misra, Raj N., Grover, Gary J., Miller, Arthur V., Ahmed, Syed Z., Kelly, Yolanda, Normandin, Diane E., Sleph, Paul G., Atwal, Karnail S.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 135 KB

english, 1999

50

Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 2. Structure-Activity Studies on Benzopyranylcyanoguanidines; Modification of the Benzopyran Ring

Atwal, Karnail S., Grover, Gary J., Ferrara, Francis N., Ahmed, Syed Z., Sleph, Paul G., Dzwonczyk, Steven, Normandin, Diane E.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 975 KB

english, 1995